1/14/2024 0 Comments Actions for animalsInternational harmonisationĪ regulatory acceptance of alternative methods is required internationally if true reduction in animal use is to be delivered. EURL ECVAM has published a series of studies to review available and emerging non-animal models being used for research in various disease areas with the aim to identify and describe specific research contexts where animal models have been put aside in favour of novel non-animal techniques. EURL ECVAM also works to advance non-animal models used in biomedical research. The Inventory of 3Rs knowledge sources is a result of an assessment of technologies, information sources and networks from all relevant sectors with potential impact on the advancement of the “Three Rs” carried out by EURL ECVAM. Among its tasks is to validate methods which replace, reduce or refine the use of animals for the safety and efficacy/potency testing of chemicals, biologicals and vaccines. The Joint Research Centre’s EU Reference Laboratory for Alternatives to Animal Testing ( EURL ECVAM), established by Directive 2010/63/EU, works on the development and promotion of non-animal approaches to testing and research. and a public-private partnership to advance alternatives in the area of regulatory use - the European Partnership for Alternative Approaches to Animal Testing (EPAA)ĮU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM).international harmonisation of regulatory testing requirements.hosting the E U Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM).The EU undertakes several activities towards these shared goals, including Refinement signifies the modification of any procedures or practices from the time the experimental animal is born until its death to minimise its suffering and enhance its well-being, or by moving from species that are considered more sentient to those less sentient. Reduction covers any approach that will result in fewer animals being used to achieve the same objective. Replacement can be defined as methods, strategies or approaches that do not involve the use of live animals. EU legislation on animals in science centers on the principle of the “Three Rs”: replacement, reduction and refinement, which first appeared in 1959.
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